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where is the mean squared correlation of allele frequencies across pairs of loci observed in the sample, and S is the sample size, with the 1/S term correcting for the sampling bias that a finite number of genotyped individuals introduces into even when the true population is large. The practical consequence practitioners have to internalize: is estimated with noise from a finite sample, and that noise itself creates apparent linkage disequilibrium indistinguishable from drift-generated LD unless it is explicitly subtracted — which is exactly what the 1/S term does, and why the estimator is only trustworthy when the sample size and locus count used to…
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Equation 24 · Biology
Evolutionary Biology and Ecology in Practice: An Advanced Technical Guide
This mathematical expression combines the displayed quantities; its precise role follows from the surrounding article text.
where is the mean squared correlation of allele frequencies across pairs of loci observed in the sample, and S is the sample size, with the 1/S term correcting for the sampling bias that a finite number of genotyped individuals introduces into even when the true population is large. The practical consequence practitioners have to internalize: is estimated with noise from a finite sample, and that noise itself creates apparent linkage disequilibrium indistinguishable from drift-generated LD unless it is explicitly subtracted — which is exactly what the 1/S term does, and why the estimator is only trustworthy when the sample size and locus count used to…
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Equation guide → · Article →Equation 28 · Biology
Evolutionary Biology and Ecology in Practice: An Advanced Technical Guide
This mathematical expression combines the displayed quantities; its precise role follows from the surrounding article text.
where is the mean squared correlation of allele frequencies across pairs of loci observed in the sample, and S is the sample size, with the 1/S term correcting for the sampling bias that a finite number of genotyped individuals introduces into even when the true population is large. The practical consequence practitioners have to internalize: is estimated with noise from a finite sample, and that noise itself creates apparent linkage disequilibrium indistinguishable from drift-generated LD unless it is explicitly subtracted — which is exactly what the 1/S term does, and why the estimator is only trustworthy when the sample size and locus count used to…