Equation 19 · Part 1 · Evolutionary Biology and Ecology in Practice: An Advanced Technical Guide
Symbol N_e
What this part means
the downward in inferred.
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is a part of this expression. Its role is fixed by the surrounding article and by the operations shown in the formula.
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Physically linked loci must be excluded or flagged , because the method’s entire logic depends on treating background disequilibrium as drift-generated between unlinked loci; loci close together on the same chromosome carry disequilibrium from physical linkage that has nothing to do with and will bias the estimate upward in apparent LD, downward in inferred .
The passage around this formula
One of the most widely used field-deployable methods for estimating from a single sample of genotypes is the linkage disequilibrium (LD) method , implemented and validated by Waples and Do in their 2008 paper introducing the LDNE software [ 3 ] . The logic: in an infinite population at linkage equilibrium, alleles at different, unlinked loci are statistically…
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Sources cited in the surrounding passage
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