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Equation 23 · Part 2 · Einstein's Random Walk and the Mathematics of Genetic Drift

Symbol p

V(p)V(p)
pp

What this part means

the starting from frequency.

Its job in the formula

p is a part of this expression. Its role is fixed by the surrounding article and by the operations shown in the formula.

Where the article explains it

Kimura’s 1962 formula for the probability that a gene with selective advantage s eventually fixes, starting from frequency p in a population of effective size N , is u(p) = 1−e−4Nsp1−e−4Ns\frac{1-e^{-4Nsp}}{1-e^{-4Ns}} as verified directly from his derivation [ 7 ] .

The passage around this formula

The same second-derivative operator acts on a diffusion term in both; only the variable and the coefficient it multiplies have changed. One honest difference is worth stating rather than smoothing over: Einstein’s D is a constant, fixed once by temperature and viscosity, while Kimura’s V(p) depends on the frequency itself, so the spread is fastest near p=0.5 and vanishes at the boundaries — an allele already fixed or already lost has nothing left to drift into [ 7 ] . The operator is identical; the coefficient it acts on has learned something about the biology.

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A variable is a named place for a value. Its letter is a local label: x can mean position in one formula and a data point in another.

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Sources cited in the surrounding passage

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