Symbol q_n+1
+1 is part of the quantity the equation computes from the expression on the right.
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Why this formula appears here
Set s = 1 , the theoretical maximum in which every affected embryo is detected and never implanted: for q = 0.01 , this gives = /(1+) 0.009901 , a reduction of under one-tenth of one percent of the allele’s frequency in a single generation, even at total, universal, perfectly effective screening. The reason the effect is so small is structural, not a modeling artifact: for a rare recessive allele, the overwhelming majority of copies are carried silently in heterozygous carriers, invisible to any selection that acts only on homozygotes, and embryo selection — like natural selection against recessive disease before it — can only ever act on the small fraction of matings…
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Symbol q_n
is one of the signed contributions combined to compute the quantity on the left.
Read this term in its guide →How to interpret it
Its accuracy depends on the assumptions and range of use described in the article. Read it with the definitions, units, and assumptions supplied by the article.
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Published contexts (1)
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Equation 6 · Technological Evolution
Human Evolution Did Not Stop, and Medicine Is Now Steering It
This equation gives an approximation: it relates the quantities while allowing an approximation.
Set s = 1 , the theoretical maximum in which every affected embryo is detected and never implanted: for q = 0.01 , this gives = /(1+) 0.009901 , a reduction of under one-tenth of one percent of the allele’s frequency in a single generation, even at total, universal, perfectly effective screening. The reason the effect is so small is structural, not a modeling artifact: for a rare recessive allele, the overwhelming majority of copies are carried silently in heterozygous carriers, invisible to any selection that acts only on homozygotes, and embryo selection — like natural selection against recessive disease before it — can only ever act on the small fraction of matings…
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