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Start with the most direct measurement available. A metal or silicon electrode placed in the extracellular space senses the potential produced by transmembrane currents in the surrounding tissue. Under the standard volume-conductor treatment, with the medium approximated as homogeneous, isotropic and purely resistive, and each current source treated as a point, the potential at position r is a superposition:
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Equation 1 · Neuroscience
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Start with the most direct measurement available. A metal or silicon electrode placed in the extracellular space senses the potential produced by transmembrane currents in the surrounding tissue. Under the standard volume-conductor treatment, with the medium approximated as homogeneous, isotropic and purely resistive, and each current source treated as a point, the potential at position r is a superposition:
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