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Equation 12 · Part 13 · Structure from Sequence: What Protein Folding Prediction Did and Did Not Settle

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p(x)=e−βF(x)∫e−βF(x′) dx′,β=1kBT,p(x) = \frac{e^{-\beta F(x)}}{\displaystyle\int e^{-\beta F(x')}\,dx'}, \qquad \beta = \frac{1}{k_{\mathrm B}T},
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What this part means

A raised number can be a power. When it is a label or bound, it selects a case or the upper limit of a sum; the formula’s structure distinguishes these uses.

Its job in the formula

A raised mark can be a power or an index. Its position and the surrounding notation determine which.

The passage around this formula

A protein in solution is not a coordinate file. It is a distribution. Under equilibrium conditions the physically meaningful object is a Boltzmann-weighted ensemble over conformations, p(x)=e−βF(x)∫e−βF(x′) dx′,β=1kBTp(x) = \frac{e^{-\beta F(x)}}{\displaystyle\int e^{-\beta F(x')}\,dx'}, \qquad \beta = \frac{1}{k_{\mathrm B}T}. and function frequently depends on the populations and interconversion rates of its modes rather than on the single most populated one. A predicted structure is a point estimate. It carries no populations, no relative free energies, and no exchange kinetics — none of which can be recovered from the file by inspection.

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Learn the underlying idea

An exponent tells how a base is used in multiplication. In x³, x is the base and 3 is the exponent: x³ = x × x × x.

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Sources cited in the article section

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