Equation 10 · Part 2 · Structure from Sequence: What Protein Folding Prediction Did and Did Not Settle
subscript
subscript
What this part means
The lower label selects a particular version, component, or indexed member of the quantity. For example, x₀ and xₜ can be values at different positions.
Its job in the formula
A subscript distinguishes a version, component, step, or member of a quantity. It does not automatically mean multiplication.
Full expression→subscript→Article meaning
The passage around this formula
with single-site fields and pair couplings fitted so that the model reproduces the single-column and pairwise frequencies of the alignment. Marks and colleagues reported that the strength of the inferred couplings is a strong predictor of residue proximity in the folded structure, and that the top-scoring couplings are accurate and well-distributed enough to define a three-dimensional fold [ 5 ] . Morcos and colleagues developed a computationally efficient direct-coupling analysis that disentangled direct from indirect correlations and evaluated contact-prediction accuracy across a large number of protein domain families from sequence information alone [ 6 ] .
Learn the underlying idea
A subscript is a label attached below a symbol. It often selects a time step, component, category, or member of a sequence.
Open the illustrated subscripts: which member of a family? guide →
Sources cited in the surrounding passage
- [5] Protein 3D Structure Computed from Evolutionary Sequence Variation ↗
- [6] Direct-coupling analysis of residue coevolution captures native contacts across many protein families ↗
These citations provide research context; check each source for the exact claim it supports.