Equation 1 · Comparing the Main Approaches to Molecular Biology and Genomics
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Symbol g
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A useful way to see the tradeoff quantitatively is coverage. If a screen library contains g guides and the experimenter wants, on average, c cells carrying each guide to survive Poisson dropout during selection, the number of cells that must be carried through the pipeline scales roughly as
Sources cited in the article section
- [1] A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity ↗
- [2] Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells ↗
- [3] Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 ↗
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