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Equation 5 · Part 8 · Comparing the Main Approaches to AI for Science and Medicine

subtraction

RMSD=1N∑i=1N∥xi−x^i∥2\text{RMSD} = \sqrt{\frac{1}{N} \sum_{i=1}^{N} \lVert x_i - \hat{x}_i \rVert^2}
subtraction

What this part means

Subtract the following term or group from the preceding one. A leading minus marks a negative quantity.

Its job in the formula

Subtract the following term or group from the preceding one. A leading minus marks a negative quantity.

The passage around this formula

AlphaFold2 was assessed in CASP14, the blind, independently organized structure-prediction assessment in which competing methods predict structures for proteins whose experimentally solved coordinates are not yet public, and are scored by assessors with no stake in any team’s outcome. Against that standard, AlphaFold2’s median backbone accuracy was 0.96 angstroms of Cα root-mean-square deviation from the experimental structure, against 2.8 angstroms for the next-best method, and its median all-atom accuracy was 1.5 angstroms against 3.5 angstroms for the next-best method [ 9 ] . What that root-mean-square-deviation figure actually measures is worth stating explicitly, because the number is…

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Learn the underlying idea

Addition combines quantities; subtraction measures the signed difference between them. Parentheses show what is combined before the rest of the expression is evaluated.

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Sources cited in the surrounding passage

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