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Equation 1 · Part 5 · Comparing the Main Approaches to AI for Science and Medicine

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N^hits  ≈  ∑sh(s) N(s)\hat{N}_{\text{hits}} \;\approx\; \sum_{s} h(s)\, N(s)
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What this part means

Approximately equal to; the equality is not exact.

Its job in the formula

Approximately equal to; the equality is not exact.

The passage around this formula

High-throughput virtual screening takes the opposite approach: rather than proposing new compositions, it exhaustively scores a library that already exists. The clearest demonstration is ultra-large library docking, in which researchers computationally docked a library of 170 million make-on-demand compounds, built from 130 well-characterized reactions, against two protein targets: AmpC beta-lactamase and the D4 dopamine receptor [ 8 ] . Against AmpC, 99 million library members were scored, 51 top-ranked compounds were selected and 44 synthesized, yielding an 11% hit rate and, after optimization, a 77-nanomolar inhibitor among the most potent non-covalent AmpC inhibitors then known. Against…

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A variable is a named place for a value. Its letter is a local label: x can mean position in one formula and a data point in another.

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Sources cited in the surrounding passage

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