#energy landscape

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A slim polyimide loop on its magnetic pin caught part-way onto a brushed-steel goniometer head, a small protein crystal held in the loop film and the cryostream nozzle spilling its first curl of cold vapour

Structure from Sequence: What Protein Folding Prediction Did and Did Not Settle

Deep-learning predictors now recover static native folds at close to experimental accuracy. That is a real answer to one question, and it leaves the questions about ensembles, dynamics and function much where they were.

By Brecht Corbeel · August 8, 2026 · 14 min read

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